S.E.M.I. – Side Effects May Include... overview

Overview

S.E.M.I. – Side Effects May Include... comes from Two Horn Unicorn and is published by Two Horn Unicorn. It arrived on Steam on Jan 23, 2026, and it sits naturally among Single-player, Multi-player, Co-op, Online Co-op, Steam Achievements, Full controller support, Custom Volume Controls, and Playable without Timed Input. SteamPulse tracks it across Windows and Steam so readers get a quick useful snapshot, not just a wall of numbers.

Players and reviews

S.E.M.I. – Side Effects May Include...'s latest SteamPulse observation recorded 0 players at 22 September 2026 - 09:08:19 UTC, with a tracked peak near 45. This peak is the highest value in the available SteamPulse record and may not include activity before tracking began. Player reaction is 86% positive across 112 reviews.

Language and system requirements

S.E.M.I. – Side Effects May Include... is available in 9 languages including:

3 regional rating boards including dejus, steam germany, and igrs

Sales, recommendations, and streams

S.E.M.I. – Side Effects May Include... has sold up to 8,404 units and has recommendation data pending. The estimated VGI revenue is $48,809. On Twitch, 0 streamers are live with around 0 total watchers.

S.E.M.I. – Side Effects May Include... overview details

S.E.M.I. – Side Effects May Include... combines live player counts with reviews, pricing, platform support, Store metadata, dated player history, media, recent news, and related games.

Steam Store description

S.E.M.I. is a cooperative online game about escaping from a special clinic. Here, you and up to 3 of your brainless loyal friends play as patients, fighting staff and other patients while stumbling into all sorts of unexpected situations. Brawls, side-effect pills, and brutal platforming will absolutely challenge your clumsy friends’ hands sense of teamwork. Expect obstacles, puzzles, deadly traps, and rooms where a single wrong move can knock out the entire squad. Communicate in voice chat and arrange sabotage help your friends pass through rooms, get out of traps and fight with opponents! In your arsenal: close combat, physics, amazing abilities and ... imagination! Take pills and get abilities : Bipolar force is an invulnerable monster, then a helpless rag! Laser astigmatism — two sights, one laser… Where will he shoot? Stendhal syndrome — are you looking at a painting? Now you're hysterical and destroying everything around you! Alice's syndrome is either tiny or gigantic — have time to adjust! Madness is near! You and your friends can go crazy and start running, jumping and fighting, and your abilities will become uncontrollable. Do you want to take back control? Take the pills :) Locations are randomly generated from rooms with changing gravity, traps, moving walls, and other "pleasant" surprises. After a successful escape, you will receive a medical report: " The patient was stable until he started hitting the guards with a bottle. Diagnosis: Overmotivation " or something worse ! Unlock new costumes and decorations. Let each new escape be more stylish th…

SteamPulse editorial summary

S.E.M.I. – Side Effects May Include... is listed as a game with $7.99. It supports Windows, belongs to Single-player, Multi-player, Co-op, Online Co-op, Steam Achievements, Full controller support, Custom Volume Controls, and Playable without Timed Input, and is associated with Action and Indie. SteamPulse's latest observation records 0 players at 22 September 2026 - 09:08:19 UTC, a tracked peak of 45, and 86% positive reviews.

Highlighted achievements

Support and legal notes

Real questions answered from SteamPulse data, including live players, monthly momentum, review sentiment, regional audience signals, Twitch activity, and current Steam pricing.